vCJD risk assessment calculations for a patient with multiple routes of exposure | National Resource for Infection Control (NRIC)

vCJD risk assessment calculations for a patient with multiple routes of exposure

Review
Abstract: 
This paper was developed in response to a request from the CJD Incidents Panel following the finding of abnormal prion protein in the spleen of a patient with haemophilia. Assuming that the abnormal protein represents a marker of vCJD infection, the paper sets the various possible routes through which such infection could have occurred, and considers their relative likelihood in various scenarios. As well as dealing with this specific “incident”, the paper sets out a more general methodology for assessing multiple possible infection routes. The analysis was considered by the Panel at its meeting on 20th May 2009. The Panel concluded that there was no evidence to change its current advice to those patients treated with UK sourced pooled plasma products between 1980 and 2001 already notified as being “at risk of vCJD for public health purposes”, or to notify any new groups of patients. This version of the paper repeats the analysis presented to the Panel, while giving slightly more background information for other readers, and is placed here for public record
Authors: 
Department of Health
Category: 
Clinical description