Diverse Sources of C. difficile Infection Identified on Whole-Genome Sequencing | National Resource for Infection Control (NRIC)

Diverse Sources of C. difficile Infection Identified on Whole-Genome Sequencing

Research study, Surveillance data
Abstract: 
It has been thought that Clostridium difficile infection is transmitted predominantly within health care settings. However, endemic spread has hampered identification of precise sources of infection and the assessment of the efficacy of interventions. Over a 3-year period, 45% of C. difficile cases in Oxfordshire were genetically distinct from all previous cases. Genetically diverse sources, in addition to symptomatic patients, play a major part in C. difficile transmission.
Authors: 
David W. EyreB.M.B.Ch.Madeleine L. CulePh.D.Daniel J. WilsonD.Phil.David GriffithsB.Sc.Alison VaughanB.Sc.Lily O'ConnorB.Sc.Camilla L.C. IpPh.D.Tanya GolubchikPh.D.Elizabeth M. BattyPh.D.John M. FinneyB.Sc.David H. WylliePh.D.Xavier DidelotD.Phil.Paolo PiazzaPh.D.Rory BowdenPh.D.Kate E. DinglePh.D.Rosalind M. HardingPh.D.Derrick W. CrookM.B.B.Ch.Mark H. WilcoxM.D.Tim E.A. PetoD.Phil.and A. Sarah WalkerPh.D. N Engl J Med 2013369:1195-1205September 262013DOI: 10.1056/NEJMoa1216064
Category: 
Control
Epidemiology