As part of its remit, the ACDP TSE Working Group produces the guidance document Transmissible spongiform encephalopathy agents: safe working and the prevention of infection. The aim of the guidance is the minimisation of the risk of transmission of CJD and vCJD. This revised guidance was published from June 2003 in sections, as they were prepared and endorsed by the then Joint ACDP and SEAC Working Group. This group were uncoupled in 2004 to become the ACDP TSE Working Group The current guidance was published in June 2003, replacing the March 1998 edition. The guidance has evolved in the years since, with new annexes being added and current guidance being updated as further scientific information becomes available or future policy decisions need to be reflected. The ACDP TSE Working Group regularly update individual sections of this guidance as further scientific information becomes available or future policy decisions need to be reflected. The date of publication for updated or revised sections is clearly indicated The format is essentially the same as the earlier 1998 publication but is now significantly expanded with additional annexes. The revised guidance contains the following: Statement on ACDP/SEAC Abbreviations Part 1 – Introduction (June 2003) Part 2 – Health and Safety management of TSEs (2 June 2003) Part 3 – Laboratory containment and control measures (15 December 2003 ) Part 4 - Infection control of CJD, vCJD and other human prion diseases in healthcare and community settings (revised and updated July 2010) (Updated 13 December 2010) http://www.dh.gov.uk/prod_consum_dh/groups/dh_digitalassets/@dh/@ab/documents/digitalasset/dh_122647.pdf Annexe A.1 – Revised Annex A1: Distribution of TSE infectivity in human tissues and body fluids. Updated 13 December 2010 Annexe A.2 – Distribution of infectivity in animal tissue and body fluids - 2 June 2003 , updated: 7 February 2007 Annex B – Diagnostic criteria - Published: 2 June 2003 updated: 22 October 2008 Annex C – General principles of decontamination and waste disposal - Published: 16 November 2009 Annex D – Transport of TSE-infected material, this Annex has recently been updated - Published: December 2003, updated: 23 January 2009 http://www.advisorybodies.doh.gov.uk/acdp/tseguidance/tseguidance_annexd.pdf Annex E – Quarantining of surgical instruments - Published: 2 June 2003, revised October 2009 Annex F – Endoscopy – Revised 2 February 2010 - Updated July 2010 Consensus statement from the BSG Decontamination Working Group and the ACDP TSE Working Group Published: November 2005, revised and updated: 2 June 2008 - Endoscopy and individuals at risk of vCJD for public health puposes – Annex G – Decontamination of other specialised equipment – This annex is currently being revised and will be available soon Annex H – After death - Updated May 2010 Information sheet for funeral directors, relatives and others following a CJD death Annex I – Outline Protocol for Management of Instruments and Tissues from Brain Biopsy Procedures on patients with progressive neurological disorders - Published: 2005, updated: May 2007 Annex J - Assessment to be carried out before surgery and endoscopy to identify patients with, or at risk of CJD - revised 2 February 2010; Updated 13 December 2010 Annex K - Guidelines for pathologists and pathology laboratories for the handling of tissues from patients with, or at risk of, CJD or vCJD - Published: March 2009 Annex L - Managing CJD vCJD risk in ophthalmology - Published September 2009; updated May 2010 and updated July 2010 Acknowledgements If you would like to receive email notification of updates to this guidance, please email firstname.lastname@example.org with the subject 'TSE guidance update'